CGP-74514A hydrochloride( CGP74514A )

Catalog No. M14612 CAS No. 481724-82-7

CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.

Purity : >98% (HPLC)

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Biological Information

Product Name

CGP-74514A hydrochloride
Note

Research use only, not for human use.
Brief Description

CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.
Description

CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells; increases p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2).
In Vitro

——
In Vivo

——
Synonyms

CGP74514A
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

Chemical Information

CAS Number

481724-82-7
Formula Weight

422.35
Molecular Formula

C19H24ClN7 · HCl
Purity

>98% (HPLC)
Solubility

——
SMILES

CCN1C=NC2=C(NC3=CC=CC(Cl)=C3)N=C(N[C@H]4[C@@H](N)CCCC4)N=C12.[H]Cl
Chemical Name

N2-((1S,2R)-2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine hydrochloride

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Dai Y, et al. Cell Cycle. 2002 Mar-Apr;1(2):143-52. 2. Yu C, et al. Cancer Res. 2003 Apr 15;63(8):1822-33. 3. Dai X, et al. Cell Cycle. 2012 Aug 15;11(16):3079-86.

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